1. Product Description

• Product Name: Anti-Aging Honey Mix with NMN and CBD
• Description: This soothing blend of high-quality honey and CBD offers a natural way to promote relaxation and restful sleep. With a potent CBD content, each jar provides a calming effect that enhances overall well-being.
• Intended Use: Oral care; designed for sublingual use.
• Physical Form: Thick, viscous liquid with a natural potential for crystallization due to NMN content.
• Packaging: 40 ml dark-colored glass jar to protect contents from light and maintain quality.
• Available Variant:
  • 2000 mg NMN + 200 mg CBD / 40 ml of pure, natural blossom honey – CPNP Reference: 4632886

2. Product Claims

• The Power of NMN:

  • NMN (Nicotinamide Mononucleotide) fuels the production of Nicotinamide Adenine Dinucleotide (NAD+), essential for energy metabolism and DNA repair. NAD+ levels naturally decline with age, but NMN supplementation aims to restore these levels, promoting cellular health and supporting longevity.

• The Benefits of CBD:

  • CBD interacts with the endocannabinoid system (ECS), which regulates physiological processes to maintain balance (homeostasis). CBD is known for pain relief, reduction of anxiety and depression, alleviation of cancer-related symptoms, and neuroprotective properties.

• Synergy in Honey:

  • Infusing NMN and CBD into honey creates a potent blend with honey acting as a natural carrier to enhance absorption, combining the beneficial effects of NMN and CBD in one product.

3. Shared Health Benefits

• Neuroprotection: Both NMN and CBD help protect nerve cells from damage.
• Improved Skin Health: CBD’s anti-inflammatory properties combined with NMN’s hydration effects contribute to healthier, more resilient skin.
• Enhanced Sleep Quality: The calming properties of CBD and the restorative effects of NMN support better sleep, which is vital for overall health and well-being.

Crystal Formation: Crystals may naturally form at the bottom of the honey due to NMN separating over time. This is a normal occurrence and does not affect product quality or efficacy. Stir before use.

4. Product Safety Report (CPSR)

Part A: Safety Information

• Quantitative and Qualitative Composition:

  • INCI Ingredients:
    • Cannabidiol (CBD) derived from extract or tincture or resin of cannabis
    • Nicotinamide Mononucleotide
    • Honey Extract
  • Available CBD Concentrations:
    • 2000 mg NMN + 200 mg CBD per 40 ml of honey

• Physical/Chemical Characteristics and Stability:

  • Store at 15°C to 25°C in a dry, dark, and cool environment.
  • Shelf life: Up to 3 years unopened; use within 12 months after opening.

• Microbiological Quality:

  • Complies with microbiological quality standards for honey-based products.
  • Heavy metal check performed under DIN EN 13657:2003-01 standards.

• Normal and Reasonably Foreseeable Use:

  • Administration: Sublingual application. Place half a teaspoon under the tongue and hold for 60-90 seconds to maximize absorption.

Part B: Safety Assessment

Prepared by: Charalambos Georgiou, Chemical Engineer

Safety Assessment for Anti-Aging Honey Mix with NMN and CBD
This product combines NMN and CBD in a honey base, carefully formulated under stringent quality and safety protocols. Based on available data, the product is considered safe when used as directed. The honey acts as a carrier for NMN and CBD, facilitating their absorption and enhancing their health benefits.

• Manufacturing Process and Quality Control:
  • CBD and NMN extracts are manufactured in GMP facilities to ensure quality and safety standards. The honey is a natural product and is processed with minimal handling to maintain its integrity. The final product formulation occurs on a small scale under controlled conditions, using a closed-loop heating mantle and a liquid filling machine. Each piece of equipment is sterilized with grain alcohol before use to ensure product purity.
  • Access to the laboratory is restricted to the Chemical Engineer, who utilizes specialized safety uniforms to maintain a contaminant-free environment. The laboratory itself is cleaned daily using isopropyl alcohol on surfaces, grain alcohol on glassware, and a robotic vacuum cleaner for vacuuming and mopping.

Storage Conditions
All finished products, along with raw materials, are stored in a shared environment designed to prevent exposure to humidity and sunlight. This storage space is consistently kept clean, ensuring the long-term stability and safety of the products.

Safety Profile and Precautions

CBD
Extensive literature indicates that CBD is non-lethal and lacks significant adverse effects, even at high doses. Unlike THC, CBD does not impact the brainstem, thus avoiding risks to vital functions such as heart rate and breathing. However, while the product is generally well-tolerated, some users may experience minor side effects if exceeding the recommended dosage. These potential side effects include dry mouth, nausea, drowsiness, changes in appetite, vomiting, and mild gastrointestinal discomfort.

CBD may also cause rare but serious allergic reactions, with symptoms such as skin rash, itching, swelling, or difficulty breathing. Individuals with allergies should discontinue use and seek medical attention if symptoms occur. Additionally, CBD can interfere with liver enzymes (cytochrome P450), potentially affecting the metabolism of certain medications, including:

• Antiepileptics
• Antidepressants
• Antipsychotics
• Anticoagulants
• Opioids
• Benzodiazepines
• Steroids
• NSAIDs

Those taking these medications should consult a healthcare provider before using CBD and consider regular liver function monitoring for long-term use. This guidance ensures safer use of CBD products in combination with other treatments.

NMN
NMN may cause rare but serious allergic reactions, with symptoms such as skin rash, itching, swelling, or difficulty breathing. Individuals with known sensitivities should discontinue use and seek medical attention if any symptoms occur. Furthermore, NMN can influence metabolic pathways related to NAD+ and may interact with specific enzymes in the liver, potentially affecting the metabolism of certain medications, including:

• Antidiabetic drugs
• Blood pressure medications
• Immunosuppressants
• Chemotherapy agents
• Anticoagulants
• Steroids
• Antiepileptics

Those taking these medications should consult a healthcare provider before using NMN and consider regular health monitoring when taking NMN over the long term. This guidance ensures safer use of NMN products in combination with other treatments and supports overall well-being.

Conclusion
The CBD and NMN Honey Extract has been formulated and produced under strict regulatory and quality control conditions, ensuring a premium product designed to promote overall wellness. Both CBD and NMN extracts are manufactured in GMP-compliant facilities, and the final product is crafted with the utmost attention to safety and cleanliness. With the synergistic benefits of CBD and NMN, this product offers users enhanced support for relaxation, neuroprotection, and energy metabolism.
While the product is generally safe for daily use, it is recommended that consumers adhere to usage guidelines and consult a healthcare professional if they are on other medications or have pre-existing health conditions. This guidance supports a more informed and beneficial experience with the unique properties of both CBD and NMN.

5. Usage Instructions

• Recommended Dose: Take half a teaspoon sublingually and hold for 60-90 seconds.
• Frequency of Use: Ideal for use in the evening or when seeking relaxation and sleep support. For best results, daily use is recommended.

6. Precautions and Additional Information

• Not a Medical Product: This product is not intended to diagnose, cure, or prevent any medical condition.
• Consultation Recommended: If you have specific health concerns or are taking other medications, consult a healthcare provider before use.
• Storage: Store in a cool, dark place. Crystallization is a natural occurrence in honey products and does not affect potency.

7. Labeling Information

• Label Includes:
  • Product name and concentrations of CBD and NMN.
  • Full ingredient list in INCI format.
  • CPNP registration number.
  • Usage instructions and recommended dosage.
  • Manufacturer’s details and batch number.
  • Net contents (40 ml).
  • Storage conditions and shelf life.
  • Precautionary statements, including “consult a healthcare professional before use.”
  • No animal testing certification.

8. References

• Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants, 9(1), 21. doi:10.3390/antiox9010021
• Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825–836. doi:10.1007/s13311-015-0387-1
• Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., … & Imai, S. I. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(5), 795-806. doi:10.1016/j.cmet.2016.09.013
• Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metabolism, 27(3), 513-528. doi:10.1016/j.cmet.2018.01.001
• Samarghandian, S., Farkhondeh, T., & Samini, F. (2017). Honey and health: A review of beneficial effects on human health. Pharmacognosy Research, 9(2), 121-127. doi:10.4103/0974-8490.204647
• Eteraf-Oskouei, T., & Najafi, M. (2013). Traditional and modern uses of natural honey in human diseases: A review. Iranian Journal of Basic Medical Sciences, 16(6), 731–742.