1. Product Description

• Product Name: Premium CBD Oil for Pets (90% Salmon Oil, 10% CBD)
• Description: Specially formulated CBD oil for pets.
• Intended Use: For oral care, designed to promote well-being in pets.
• Physical Form: Liquid, packaged in a 10 ml dark-colored glass bottle with a dosing pipette.
• Packaging: Glass bottle, approved by EU standards, ensuring safety and quality.

2. Benefits

• Pain Relief: May alleviate pain and discomfort in your pet.
• Anti-Inflammatory: Can reduce inflammation, helpful for conditions like arthritis.
• Stress and Anxiety Reduction: Calms pets, reducing anxiety and stress symptoms.
• Improved Digestion: Enhances digestion and appetite.
• Coat and Skin Health: Salmon oil supports a healthier skin and coat.
• Boosted Immunity: Regular use may strengthen your pet’s immune system.

These benefits help enhance your pet’s overall health, making this CBD oil an ideal addition to their care routine.

Scientific References

1. Mlost, J., Bryk, M., & Starowicz, K. (2020). International Journal of Molecular Sciences, 21(22), 8870.
2. Philpott, H. T., O’Brien, M., & McDougall, J. J. (2017). Pain, 158(12), 2442–2451.
3. Blessing, E. M., et al. (2015). Neurotherapeutics, 12(4), 825–836.
4. Schuelert, N., & McDougall, J. J. (2011). Arthritis Research & Therapy, 13(2), R57.
5. Calder, P. C. (2013). British Journal of Clinical Pharmacology, 75(3), 645–662.
6. Alavi, F., et al. (2015). Advances in Biological Research, 9(3), 153-160.
7. Russo, E. B. (2008). Therapeutics and Clinical Risk Management, 4(1), 245–259.

3. Active Ingredients

• Composition:
  • Cannabidiol (CBD) from hemp extract or resin
  • Salmon Oil, for additional health benefits

4. Administration Method

• Directly administer the CBD oil to your pet using the dropper or mix it into their food or treats.

5. Storage Conditions and Shelf-Life

• Storage: Keep between 15°C and 25°C in a dry, dark, cool place. For optimal omega-3 preservation, refrigerate after opening.
• Shelf Life: Lasts up to 3 years when unopened. Once opened, use within 12 months.

6. Packaging and Dosing

• Packaging: 10 ml dark-colored glass bottle with dosing pipette, meeting EU regulations.
• Recommended Dose:
  • For dogs (9-27 kg): 1-3 drops daily
  • For cats (4.5 kg): 1-2 drops daily
• Safety Check: Heavy metal check completed under DIN EN 13657: 2003-01 standards.

7. Product Safety Report

Part A: Safety Information

• Physical/Chemical Characteristics: Store as recommended above for optimal stability.
• Microbiological Quality: Complies with required standards.
• Packaging and Traces: Certified safe, with a heavy metal check.
• Use: Place oil under the tongue for 3-5 minutes.

Part B: Safety Assessment

Assessment by Charalambos Georgiou, Chemical Engineer
This CBD oil is made with high-quality salmon oil and CBD extract which follows c-GMP standards for purity and potency. Salmon oil complies with ISO 22000 and ISO 9001, ensuring quality and safety. The final product is prepared in a controlled environment under the strict supervision of a Chemical Engineer, maintaining top hygiene standards.

Manufacturing Process and Quality Control
Each batch is produced in a small, closed-loop system and sterilized with grain alcohol. The laboratory is sanitized daily to ensure a safe product for your pet.

Storage
Both raw materials and finished products are stored in a clean, shared environment to maintain long-term stability.

Precautions

While CBD oil is generally considered safe for most pets, some animals may experience mild side effects, especially if given higher-than-recommended doses. Potential side effects include:

Dry Mouth: CBD may reduce saliva production, leading to dry mouth. This can sometimes cause pets to drink more water.

Drowsiness: Due to its calming effects, CBD can cause drowsiness, particularly if taken in high doses.

Low Blood Pressure: High doses of CBD can temporarily cause a drop in blood pressure, resulting in light-headedness or drowsiness in pets.

Gastrointestinal Issues: Pets may experience mild digestive issues like diarrhea or reduced appetite, especially if CBD is new to their diet.

Changes in Appetite: CBD may increase or decrease appetite depending on the pet and dosage.

Interactions with Medications: CBD can interfere with liver enzymes (cytochrome P450), which affects how the liver metabolizes certain medications.

Reference:

Gamble, L. J., Boesch, J. M., Frye, C. W., Schwark, W. S., Mann, S., Wolfe, L., Brown, H., Berthelsen, E. S., & Wakshlag, J. J. (2018). Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. Frontiers in Veterinary Science, 5, 165. https://doi.org/10.3389/fvets.2018.00165

McGrath, S., Bartner, L. R., Rao, S., Packer, R. A., & Gustafson, D. L. (2019). Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. Journal of the American Veterinary Medical Association, 254(11), 1301-1308. https://doi.org/10.2460/javma.254.11.1301

Klein, B. D., Lin, S., Friedman, L. K., & Specter, S. (2015). Cannabinoids: Old compounds with novel applications. Neuropharmacology, 96, 89-96. https://doi.org/10.1016/j.neuropharm.2014.10.021

Deabold, K. A., Schwark, W. S., Wolf, L., & Wakshlag, J. J. (2019). Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats. Animals, 9(10), 832. https://doi.org/10.3390/ani9100832

Silver, R. J. (2019). The Endocannabinoid System of Animals. Animals, 9(9), 686. https://doi.org/10.3390/ani9090686

Baron, E. P. (2015). Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been…. Headache: The Journal of Head and Face Pain, 55(6), 885–916. https://doi.org/10.1111/head.12570